Polar Body Biopsy in the Diagnosis of Monogenic Diseases
نویسندگان
چکیده
منابع مشابه
[Preimplantation genetic diagnosis of monogenic diseases].
Preimplantation genetic diagnosis (PGD) is an alternative to prenatal diagnosis allowing the detection of genetic diseases on IVF embryos before their transfer into the uterus and before the pregnancy. The aim of this procedure is to obtain unaffected or carrier embryos in order to avoid the burden of termination of pregnancy after prenatal diagnosis for couples at risk of transmitting particul...
متن کاملBlastocyst biopsy and vitrification are effective for preimplantation genetic diagnosis of monogenic diseases.
STUDY QUESTION What is the value of a new strategy for preimplantation genetic diagnosis (PGD) of monogenic diseases: blastocyst biopsy, cryopreservation and thawed embryo transfer? SUMMARY ANSWER This strategy is highly effective for PGD of monogenic diseases and merits wide use. WHAT IS KNOWN ALREADY PGD of monogenic diseases is conventionally performed on 6- to 8-cell embryos with fresh ...
متن کاملPreimplantation diagnosis in Switzerland--birth of a healthy child after polar body biopsy.
In Switzerland preimplantation genetic diagnosis is limited by law to polar body biopsy (PBB). The indications for PBB include unexplained recurrent miscarriage and improvement of the outcome of in vitro fertilisation (IVF) cycles in women at an advanced reproductive age. In this article we report the first birth of a healthy child after polar body biopsy in Switzerland in a case of unexplained...
متن کاملClinical Considerations of Preimplantation Genetic Diagnosis for Monogenic Diseases
PURPOSE The aim of this study was to explore factors contribute to the success of PGD cycles for monogenic diseases. METHODS During a 3-year period (January 2009 to December 2012), 184 consecutive ICSI-PGD cycles for monogenic diseases reaching the ovum pick-up and fresh embryo-transfer stage performed at the Reproductive Medicine Center of The First Affiliated Hospital Of Sun Yat-sen Univers...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2009
ISSN: 1866-0452
DOI: 10.3238/arztebl.2009.0533